CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10) , Biotin conjugate , 0.1mg / mL

CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain , a transmembrane domain , and a cytoplasmic tail. Alternate transcriptional splice variants , encoding different isoforms , have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond , while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus , Graves disease , Hashimoto thyroiditis , celiac disease , systemic lupus erythematosus , thyroid-associated orbitopathy , and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.