TSH-Receptor , A-Chain (Thyroid Marker) (TSHRA/1401) , 1mg / mL

Thyroid-stimulating hormone (TSH , also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism , which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR) , which is cleaved into two subunits , A and B , and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease , an autoimmune disorder , TSHR is activated by autoantibodies , which may be stimulated by the cleavage of the A and B subunits.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.